Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50028604 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_54601 |
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Ki | 18±n/a nM |
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Citation | Piper, JR; McCaleb, GS; Montgomery, JA; Kisliuk, RL; Gaumont, Y; Sirotnak, FM 10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism. J Med Chem25:877-80 (1982) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_MOUSE | Dhfr |
Type: | Enzyme |
Mol. Mass.: | 21608.82 |
Organism: | Mus musculus (Mouse) |
Description: | n/a |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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BDBM50028604 |
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n/a |
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Name | BDBM50028604 |
Synonyms: | 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-octyl-amino]-benzoylamino}-pentanedioic acid | CHEMBL171757 |
Type | Small organic molecule |
Emp. Form. | C27H36N8O5 |
Mol. Mass. | 552.6253 |
SMILES | CCCCCCCCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O |
Structure |
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