| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50024142 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_195753 |
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| IC50 | 13±n/a nM |
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| Citation |  Thaisrivongs, S; Pals, DT; Kati, WM; Turner, SR; Thomasco, LM; Watt, W Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues. J Med Chem29:2080-7 (1986) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50024142 |
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| n/a |
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| Name | BDBM50024142 |
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| Synonyms: | CHEMBL3142183 | {1-[1-(1-Benzyl-3,3-difluoro-2-hydroxy-3-{2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-propylcarbamoyl)-2-(2H-imidazol-2-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C43H54F2N8O7 |
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| Mol. Mass. | 832.9351 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)C(F)(F)[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC1N=CC=N1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)NCc1ccccn1 |c:28,30| |
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| Structure | 
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