| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50226277 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54888 (CHEMBL666942) |
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| IC50 | 5.98±n/a nM |
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| Citation |  Piper, JR; McCaleb, GS; Montgomery, JA; Kisliuk, RL; Gaumont, Y; Sirotnak, FM Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid. J Med Chem29:1080-7 (1986) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_LACCA | dhfR | folA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 18437.08 |
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| Organism: | Lactobacillus casei |
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| Description: | ChEMBL_1357878 |
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| Residue: | 163 |
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| Sequence: | MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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| BDBM50226277 |
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| n/a |
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| Name | BDBM50226277 |
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| Synonyms: | CHEMBL273509 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N6O6 |
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| Mol. Mass. | 468.4626 |
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| SMILES | CN(Cc1cnc2nc(N)nc(O)c2c1C)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O |
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| Structure | 
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