Reaction Details |
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Target | Thymidylate synthase |
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Ligand | BDBM50226277 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_210164 (CHEMBL813846) |
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IC50 | 2.78±n/a nM |
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Citation | Piper, JR; McCaleb, GS; Montgomery, JA; Kisliuk, RL; Gaumont, Y; Sirotnak, FM Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid. J Med Chem29:1080-7 (1986) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thymidylate synthase |
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Name: | Thymidylate synthase |
Synonyms: | TSase | TYSY_LACCA | Thymidylate Synthase (TS) | Thymidylate synthase | thyA |
Type: | Enzyme |
Mol. Mass.: | 36576.54 |
Organism: | Lactobacillus casei |
Description: | n/a |
Residue: | 316 |
Sequence: | MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSE
LLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHE
EMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRL
IVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV
AHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIK
LLNYDPYPAIKAPVAV
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BDBM50226277 |
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n/a |
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Name | BDBM50226277 |
Synonyms: | CHEMBL273509 |
Type | Small organic molecule |
Emp. Form. | C22H24N6O6 |
Mol. Mass. | 468.4626 |
SMILES | CN(Cc1cnc2nc(N)nc(O)c2c1C)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O |
Structure |
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