Reaction Details |
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Target | Purine nucleoside phosphorylase |
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Ligand | BDBM50022243 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_162174 |
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IC50 | 1550±n/a nM |
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Citation | Sircar, JC; Suto, MJ; Scott, ME; Dong, MK; Gilbertsen, RB Inhibitors of human purine nucleoside phosphorylase. Synthesis, purine nucleoside phosphorylase inhibition, and T-cell cytotoxicity of 2,5-diaminothiazolo[5,4-d]pyrimidin-7(6H)-one and 2,5-diaminothiazolo[4,5-d]pyrimidin-7(6H)-one. Two thio isosteres of 8-aminoguanine. J Med Chem29:1804-6 (1986) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Purine nucleoside phosphorylase |
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Name: | Purine nucleoside phosphorylase |
Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
Type: | Enzyme |
Mol. Mass.: | 32119.53 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 289 |
Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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BDBM50022243 |
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n/a |
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Name | BDBM50022243 |
Synonyms: | 2,8-Diamino-1,9-dihydro-purin-6-one | 8-AMINOGUANINE | CHEMBL8040 |
Type | Small organic molecule |
Emp. Form. | C5H6N6O |
Mol. Mass. | 166.1407 |
SMILES | Nc1nc2nc(N)[nH]c(=O)c2[nH]1 |
Structure |
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