| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thymidylate synthase |
|---|
| Ligand | BDBM50023636 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_209138 |
|---|
| Ki | 310±n/a nM |
|---|
| Citation |  Chang, G; Schwepler, D; Decedue, CJ; Balzarini, J; De Clercq, E; Mertes, MP Linear free energy relationship studies of enzyme active site binding: thymidylate synthase. J Med Chem31:1141-7 (1988) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thymidylate synthase |
|---|
| Name: | Thymidylate synthase |
|---|
| Synonyms: | TSase | TYSY_LACCA | Thymidylate Synthase (TS) | Thymidylate synthase | thyA |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36576.54 |
|---|
| Organism: | Lactobacillus casei |
|---|
| Description: | n/a |
|---|
| Residue: | 316 |
|---|
| Sequence: | MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSE
LLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHE
EMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRL
IVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV
AHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIK
LLNYDPYPAIKAPVAV
|
|
|
|---|
| BDBM50023636 |
|---|
| n/a |
|---|
| Name | BDBM50023636 |
|---|
| Synonyms: | CHEMBL3144190 | Phosphoric acid mono-{5-[5-(4-benzyloxy-phenyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-3-hydroxy-tetrahydro-furan-2-ylmethyl} ester |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23N2O9P |
|---|
| Mol. Mass. | 490.3998 |
|---|
| SMILES | O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(-c2ccc(OCc3ccccc3)cc2)c(=O)[nH]c1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
