Ki Summary

Reaction Details

Report a problem with these data

Target

5-hydroxytryptamine receptor 1A

Ligand

BDBM50020131

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_1423

41±n/a nM

Citation

Abou-Gharbia, M; Patel, UR; Webb, MB; Moyer, JA; Andree, TH; Muth, EA Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies. J Med Chem31:1382-92 (1988) [PubMed]

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1A

Name:

5-hydroxytryptamine receptor 1A

Synonyms:

5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

46445.29

Organism:

Rattus norvegicus (rat)

Description:

Binding assays were performed using rat hippocampal membranes.

Residue:

422

Sequence:

MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR

BDBM50020131

n/a

Name

BDBM50020131

Synonyms:

4-{4-[4-(3-chlorophenyl)hexahydro-1-pyrazinyl]butyl}-4-azatetracyclo[5.4.2.02,6.08,11]trideca-9,12-diene-3,5-dione;Hydrochloride | CHEMBL31197

Type

Small organic molecule

Emp. Form.

C26H30ClN3O2

Mol. Mass.

451.988

SMILES

Clc1cccc(c1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3C=CC43)C2=O)CC1 |c:22,27,(27.22,-15.51,;25.9,-16.29,;25.9,-17.83,;24.56,-18.6,;23.24,-17.83,;23.25,-16.29,;24.56,-15.53,;21.9,-15.51,;20.58,-16.28,;19.24,-15.51,;19.26,-13.98,;17.93,-13.21,;16.6,-13.98,;15.27,-13.21,;13.94,-13.98,;12.61,-13.21,;12.44,-11.68,;13.57,-10.65,;10.94,-11.36,;10.16,-12.7,;8.6,-12.7,;9.94,-11.94,;8.85,-10.85,;10.17,-10.01,;8.6,-10.03,;7.28,-9.26,;6.51,-10.59,;7.83,-11.36,;11.19,-13.83,;10.88,-15.33,;20.59,-13.21,;21.93,-13.98,)|

Structure