Reaction Details | |||
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Target | 5-hydroxytryptamine receptor 1A | ||
Ligand | BDBM50020116 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_1423 | ||
Ki | 122±n/a nM | ||
Citation | Abou-Gharbia, M; Patel, UR; Webb, MB; Moyer, JA; Andree, TH; Muth, EA Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies. J Med Chem31:1382-92 (1988) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 1A | |||
Name: | 5-hydroxytryptamine receptor 1A | ||
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 46445.29 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | Binding assays were performed using rat hippocampal membranes. | ||
Residue: | 422 | ||
Sequence: |
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BDBM50020116 | |||
n/a | |||
Name | BDBM50020116 | ||
Synonyms: | 4-[4-(6'-Chloro-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-yl)-butyl]-4-aza-tricyclo[5.4.2.0*2,6*]tridec-12-ene-3,5-dione;Hydrochloride | CHEMBL412258 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H32ClN5O2 | ||
Mol. Mass. | 457.996 | ||
SMILES | Clc1cncc(n1)N1CCN(CCCCN2C(=O)C3C(C4CCCCC3C=C4)C2=O)CC1 |c:28,(24.8,-19.6,;24.8,-18.06,;26.15,-17.31,;26.15,-15.77,;24.83,-14.99,;23.51,-15.76,;23.49,-17.3,;22.17,-14.97,;20.83,-15.74,;19.52,-14.97,;19.52,-13.45,;18.2,-12.68,;16.86,-13.45,;15.53,-12.68,;14.2,-13.45,;12.88,-12.68,;12.69,-11.16,;13.85,-10.12,;11.21,-10.83,;10.42,-12.17,;8.88,-12.18,;8.11,-10.84,;6.77,-10.06,;7.54,-8.72,;8.88,-9.49,;10.44,-9.49,;9.11,-10.31,;10.2,-11.38,;11.44,-13.3,;11.15,-14.81,;20.85,-12.66,;22.17,-13.43,)| | ||
Structure |