Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 1A

Ligand

BDBM50020142

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_1423

14±n/a nM

Citation

Abou-Gharbia, M; Patel, UR; Webb, MB; Moyer, JA; Andree, TH; Muth, EA Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies. J Med Chem31:1382-92 (1988) [PubMed]

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1A

Name:

5-hydroxytryptamine receptor 1A

Synonyms:

5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

46445.29

Organism:

Rattus norvegicus (rat)

Description:

Binding assays were performed using rat hippocampal membranes.

Residue:

422

Sequence:

MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR

BDBM50020142

n/a

Name

BDBM50020142

Synonyms:

4-{4-[4-(3-chlorophenyl)hexahydro-1-pyrazinyl]butyl}-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene-3,5-dione;Hydrochloride | CHEMBL29326

Type

Small organic molecule

Emp. Form.

C25H30ClN3O2

Mol. Mass.

439.978

SMILES

Clc1cccc(c1)N1CCN(CCCCN2C(=O)C3C(C4C=CC3C3CC43)C2=O)CC1 |c:22,(21.6,-11.25,;20.27,-12.02,;20.27,-13.58,;18.94,-14.33,;17.62,-13.56,;17.63,-12.02,;18.94,-11.25,;16.28,-11.25,;14.96,-12.02,;13.62,-11.25,;13.64,-9.72,;12.31,-8.95,;10.99,-9.72,;9.65,-8.95,;8.33,-9.72,;6.99,-8.95,;5.57,-9.58,;5.26,-11.06,;4.55,-8.43,;5.33,-7.09,;4.56,-5.77,;3.23,-6.58,;4.32,-7.67,;2.99,-8.46,;2.22,-7.11,;1.45,-5.77,;2.99,-5.77,;6.82,-7.43,;7.95,-6.38,;14.97,-8.95,;16.3,-9.72,)|

Structure