| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
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| Ligand | BDBM50016575 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_32099 |
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| IC50 | 31000±n/a nM |
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| Citation |  DeRuiter, J; Borne, RF; Mayfield, CA N- and 2-substituted N-(phenylsulfonyl)glycines as inhibitors of rat lens aldose reductase. J Med Chem32:145-51 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 |
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| Name: | Aldo-keto reductase family 1 member B1 |
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| Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35797.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1512484 |
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| Residue: | 316 |
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| Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
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| BDBM50016575 |
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| n/a |
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| Name | BDBM50016575 |
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| Synonyms: | (4-Methoxy-benzenesulfonylamino)-acetic acid | 2-(4-methoxyphenylsulfonamido)acetic acid | CHEMBL444802 | US20230357139, Compound H |
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| Type | Small organic molecule |
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| Emp. Form. | C9H11NO5S |
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| Mol. Mass. | 245.252 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)NCC(O)=O |
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| Structure | 
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