Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50017444 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1183 (CHEMBL615949) |
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Ki | 45±n/a nM |
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Citation | Abou-Gharbia, M; Moyer, JA; Patel, U; Webb, M; Schiehser, G; Andree, T; Haskins, JT Synthesis and structure-activity relationship of substituted tetrahydro- and hexahydro-1,2-benzisothiazol-3-one 1,1-dioxides and thiadiazinones: potential anxiolytic agents. J Med Chem32:1024-33 (1989) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50017444 |
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n/a |
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Name | BDBM50017444 |
Synonyms: | 4-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-butyl}-3,3-dioxo-3lambda*6*-thia-4-aza-tricyclo[5.2.1.0*2,6*]decan-5-one; dihydrochloride | CHEMBL3216410 |
Type | Small organic molecule |
Emp. Form. | C22H33Cl4N3O3S |
Mol. Mass. | 561.393 |
SMILES | Cl.Cl.Cl.Clc1cccc(c1)N1CCN(CCCCN2C(=O)C3C4CCC(C4)C3S2(=O)=O)CC1 |
Structure |
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