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TargetThromboxane A2 Synthase (P450 TxA2)
LigandBDBM50318494
Substrate/Competitorn/a
Meas. Tech.ChEMBL_209952
IC50 1000000±n/a nM
Citation Archibald JLBradley GOpalko AWard TJWhite JCEnnis CShepperson NB Design of an antithrombotic-antihypertensive agent (Wy 27569). Synthesis and evaluation of a series of 2-heteroaryl-substituted dihydropyridines. J Med Chem 33:646-52 (1990) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thromboxane A2 Synthase (P450 TxA2)
Name:Thromboxane-A synthase
Synonyms:Cytochrome P450 5A1 | P450 TxA2 | TXA synthase | TXS | Thromboxane A2 Synthase | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase
Type:Enzyme
Mol. Mass.:60524.67
Organism:Homo sapiens (Human)
Description:P24557
Residue:533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
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  Blast E-value cutoff:
BDBM50318494
n/a
NameBDBM50318494
Synonyms:3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | CHEMBL475534 | NITRENDIPINE | cid_4507
TypeSmall organic molecule
Emp. Form.C18H20N2O6
Mol. Mass.360.3612
SMILESCCOC(=O)C1=C(C)N=C(C)C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC |c:5,t:8|
Structure
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