Found 46 hits with Last Name = 'ennis' and Initial = 'c' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552035
(CHEMBL4792698)Show SMILES CCCCc1cn(nn1)-c1ccc(NC(=O)Nc2cc(OC3CCOC3)ccc2C)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552040
(CHEMBL4764675)Show SMILES CC(C)CCc1cn(nn1)-c1ccc(NC(=O)Nc2cccc3cnccc23)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552034
(CHEMBL4743218)Show SMILES CCCCc1cn(nn1)-c1ccc(NC(=O)Nc2cc(OC3CCCC3)ccc2C)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552041
(CHEMBL4744776)Show SMILES CCCCc1cn(nn1)-c1ccc(NC(=O)Nc2cccc3cnccc23)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50537058
(CHEMBL4531719)Show InChI InChI=1S/C20H23N5O/c1-3-4-8-17-14-25(24-23-17)18-12-10-16(11-13-18)21-20(26)22-19-9-6-5-7-15(19)2/h5-7,9-14H,3-4,8H2,1-2H3,(H2,21,22,26) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552022
(CHEMBL4785115)Show SMILES CC(C)CC(=O)OCCc1cn(nn1)-c1ccc(NC(=O)Nc2ccccc2C(F)(F)F)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552031
(CHEMBL4741968)Show SMILES CCCCc1cn(nn1)-c1ccc(NC(=O)Nc2cc(O)ccc2C)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50014917
(4-(2-Chloro-phenyl)-2-imidazol-1-ylmethyl-6-methyl...)Show SMILES CCOC(=O)C1=C(Cn2ccnc2)N=C(C)C(C1c1ccccc1Cl)C(=O)OC |c:5,t:14| Show InChI InChI=1S/C21H22ClN3O4/c1-4-29-21(27)19-16(11-25-10-9-23-12-25)24-13(2)17(20(26)28-3)18(19)14-7-5-6-8-15(14)22/h5-10,12,17-18H,4,11H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368043
(CHEMBL1203671)Show SMILES CCOC(=O)C1=C(Cn2ccnc2)N=C(Cn2ccnc2)C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC |c:5,t:14| Show InChI InChI=1S/C24H24N6O6/c1-3-36-24(32)22-19(13-29-10-8-26-15-29)27-18(12-28-9-7-25-14-28)21(23(31)35-2)20(22)16-5-4-6-17(11-16)30(33)34/h4-11,14-15,20-21H,3,12-13H2,1-2H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552032
(CHEMBL4742331)Show SMILES CCCCc1cn(nn1)-c1ccc(NC(=O)Nc2cc(OCOC)ccc2C)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552024
(CHEMBL4741684)Show SMILES CCOP(=O)(OCC)OCCc1cn(nn1)-c1ccc(NC(=O)Nc2ccccc2C)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552033
(CHEMBL4787707)Show SMILES CCCCc1cn(nn1)-c1ccc(NC(=O)Nc2cc(OP(=O)(OCC)OCC)ccc2C)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 940 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552037
(CHEMBL4784714) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50014907
(4-(2-Difluoromethoxy-phenyl)-2-imidazol-1-ylmethyl...)Show SMILES CCOC(=O)C1=C(Cn2ccnc2)N=C(C)C(C1c1ccccc1OC(F)F)C(=O)OC |c:5,t:14| Show InChI InChI=1S/C22H23F2N3O5/c1-4-31-21(29)19-15(11-27-10-9-25-12-27)26-13(2)17(20(28)30-3)18(19)14-7-5-6-8-16(14)32-22(23)24/h5-10,12,17-18,22H,4,11H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552023
(CHEMBL4799050)Show SMILES CC(C)CC(=O)OCCc1cn(nn1)-c1ccc(NC(=O)Nc2ccccc2C)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368036
(CHEMBL1203682)Show SMILES CCOC(=O)C1C(C(C(=O)OCC)=C(Cn2ccnc2)N=C1C)c1cccc(c1)[N+]([O-])=O |c:21,t:12| Show InChI InChI=1S/C22H24N4O6/c1-4-31-21(27)18-14(3)24-17(12-25-10-9-23-13-25)20(22(28)32-5-2)19(18)15-7-6-8-16(11-15)26(29)30/h6-11,13,18-19H,4-5,12H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368045
(CHEMBL1203652)Show SMILES CCOC(=O)C1=C(COCc2ccncc2)N=C(C)C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC |c:5,t:17| Show InChI InChI=1S/C24H25N3O7/c1-4-34-24(29)22-19(14-33-13-16-8-10-25-11-9-16)26-15(2)20(23(28)32-3)21(22)17-6-5-7-18(12-17)27(30)31/h5-12,20-21H,4,13-14H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552038
(CHEMBL4790390)Show SMILES CCOCc1cn(nn1)-c1ccc(NC(=O)Nc2cc(ccc2C)C(C)C)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368040
(CHEMBL1203686)Show SMILES CCOC(=O)C1=C(Cn2ccnc2)N=C(C)C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C |c:5,t:14| Show InChI InChI=1S/C23H26N4O6/c1-5-32-22(28)21-18(12-26-10-9-24-13-26)25-15(4)19(23(29)33-14(2)3)20(21)16-7-6-8-17(11-16)27(30)31/h6-11,13-14,19-20H,5,12H2,1-4H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552039
(CHEMBL4795681)Show SMILES CCOC(=O)CCc1cn(nn1)-c1ccc(NC(=O)Nc2ccccc2C(F)(F)F)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368033
(CHEMBL1203626)Show SMILES CCOC(=O)C1C(C(C(=O)OC)=C(Cn2ccnc2)N=C1C)c1cccc(c1)[N+]([O-])=O |c:20,t:11| Show InChI InChI=1S/C21H22N4O6/c1-4-31-21(27)17-13(2)23-16(11-24-9-8-22-12-24)19(20(26)30-3)18(17)14-6-5-7-15(10-14)25(28)29/h5-10,12,17-18H,4,11H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368037
(CHEMBL1744226)Show SMILES CCOC(=O)C1C(C(C(=O)OCC)=C(CCn2ccnc2)N=C1C)c1ccccc1[N+]([O-])=O |c:22,t:12| Show InChI InChI=1S/C23H26N4O6/c1-4-32-22(28)19-15(3)25-17(10-12-26-13-11-24-14-26)21(23(29)33-5-2)20(19)16-8-6-7-9-18(16)27(30)31/h6-9,11,13-14,19-20H,4-5,10,12H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552036
(CHEMBL4761720)Show SMILES CCCCc1cn(nn1)-c1ccc(NC(=O)Nc2cc(CCC(C)=O)ccc2C)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM7962
(4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...)Show InChI InChI=1S/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552027
(CHEMBL4742051)Show SMILES CN(C)CCCc1cn(nn1)-c1ccc(NC(=O)Nc2ccccc2C)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50014918
(2-Imidazol-1-ylmethyl-6-methyl-4-(2-nitro-phenyl)-...)Show SMILES CCOC(=O)C1=C(Cn2ccnc2)N=C(C)C(C1c1ccccc1[N+]([O-])=O)C(=O)OC |c:5,t:14| Show InChI InChI=1S/C21H22N4O6/c1-4-31-21(27)19-15(11-24-10-9-22-12-24)23-13(2)17(20(26)30-3)18(19)14-7-5-6-8-16(14)25(28)29/h5-10,12,17-18H,4,11H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368034
(CHEMBL1203674)Show SMILES CCOC(=O)C1=C(Cn2ccnc2)N=C(C)C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC |c:5,t:14| Show InChI InChI=1S/C21H22N4O6/c1-4-31-21(27)19-16(11-24-9-8-22-12-24)23-13(2)17(20(26)30-3)18(19)14-6-5-7-15(10-14)25(28)29/h5-10,12,17-18H,4,11H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552021
(CHEMBL4764209)Show SMILES FC(F)(F)c1ccccc1NC(=O)Nc1ccc(cc1)-n1cc(CCOC(=O)\C=C\c2ccc3OCOc3c2)nn1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368032
(CHEMBL1203662)Show SMILES CCOC(=O)C1C(C(C(=O)OCC)=C(CCn2ccnc2)N=C1CCn1ccnc1)c1cccc(c1)[N+]([O-])=O |c:22,t:12| Show InChI InChI=1S/C27H30N6O6/c1-3-38-26(34)24-21(8-12-31-14-10-28-17-31)30-22(9-13-32-15-11-29-18-32)25(27(35)39-4-2)23(24)19-6-5-7-20(16-19)33(36)37/h5-7,10-11,14-18,23-24H,3-4,8-9,12-13H2,1-2H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368031
(CHEMBL1203654)Show SMILES CCOC(=O)C1C(C(C(=O)OCC)=C(CCn2ccnc2)N=C1C)c1cccc(c1)[N+]([O-])=O |c:22,t:12| Show InChI InChI=1S/C23H26N4O6/c1-4-32-22(28)19-15(3)25-18(9-11-26-12-10-24-14-26)21(23(29)33-5-2)20(19)16-7-6-8-17(13-16)27(30)31/h6-8,10,12-14,19-20H,4-5,9,11H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552025
(CHEMBL4786545)Show SMILES OCCc1cn(nn1)-c1ccc(NC(=O)Nc2ccccc2C(F)(F)F)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.12E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368042
(CHEMBL1203687)Show SMILES COC(=O)C1C(C(C(=O)OC)=C(Cn2ccnc2)N=C1C)c1cccc(c1)[N+]([O-])=O |c:19,t:10| Show InChI InChI=1S/C20H20N4O6/c1-12-16(19(25)29-2)17(13-5-4-6-14(9-13)24(27)28)18(20(26)30-3)15(22-12)10-23-8-7-21-11-23/h4-9,11,16-17H,10H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.18E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368041
(CHEMBL1203653)Show SMILES CCOC(=O)C1=C(COc2ccncc2)N=C(C)C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC |c:5,t:16| Show InChI InChI=1S/C23H23N3O7/c1-4-32-23(28)21-18(13-33-17-8-10-24-11-9-17)25-14(2)19(22(27)31-3)20(21)15-6-5-7-16(12-15)26(29)30/h5-12,19-20H,4,13H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552026
(CHEMBL4783844) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50014919
(4-(2,3-Dichloro-phenyl)-2-imidazol-1-ylmethyl-6-me...)Show SMILES CCOC(=O)C1=C(Cn2ccnc2)N=C(C)C(C1c1cccc(Cl)c1Cl)C(=O)OC |c:5,t:14| Show InChI InChI=1S/C21H21Cl2N3O4/c1-4-30-21(28)18-15(10-26-9-8-24-11-26)25-12(2)16(20(27)29-3)17(18)13-6-5-7-14(22)19(13)23/h5-9,11,16-17H,4,10H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50014908
(4-(2-Chloro-3-trifluoromethyl-phenyl)-2-imidazol-1...)Show SMILES CCOC(=O)C1=C(Cn2ccnc2)N=C(C)C(C1c1cccc(c1Cl)C(F)(F)F)C(=O)OC |c:5,t:14| Show InChI InChI=1S/C22H21ClF3N3O4/c1-4-33-21(31)18-15(10-29-9-8-27-11-29)28-12(2)16(20(30)32-3)17(18)13-6-5-7-14(19(13)23)22(24,25)26/h5-9,11,16-17H,4,10H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368039
(CHEMBL1202293)Show SMILES CCOC(=O)C1=C(Cn2ccnc2)N=C(C)C(C1c1c(F)cccc1Cl)C(=O)OC |c:5,t:14| Show InChI InChI=1S/C21H21ClFN3O4/c1-4-30-21(28)18-15(10-26-9-8-24-11-26)25-12(2)16(20(27)29-3)19(18)17-13(22)6-5-7-14(17)23/h5-9,11,16,19H,4,10H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368044
(CHEMBL1203649)Show SMILES CCOC(=O)C1=C(Cn2ccnc2)N=C(C)C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)(C)C |c:5,t:14| Show InChI InChI=1S/C24H28N4O6/c1-6-33-22(29)21-18(13-27-11-10-25-14-27)26-15(2)19(23(30)34-24(3,4)5)20(21)16-8-7-9-17(12-16)28(31)32/h7-12,14,19-20H,6,13H2,1-5H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50014902
(4-(2-Difluoromethoxy-phenyl)-2-imidazol-1-ylmethyl...)Show SMILES CCOC(=O)C1C(C(C(=O)OC)=C(Cn2ccnc2)N=C1C)c1ccccc1OC(F)F |c:20,t:11| Show InChI InChI=1S/C22H23F2N3O5/c1-4-31-21(29)17-13(2)26-15(11-27-10-9-25-12-27)19(20(28)30-3)18(17)14-7-5-6-8-16(14)32-22(23)24/h5-10,12,17-18,22H,4,11H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552028
(CHEMBL4764635)Show SMILES CN1CCN(CCCc2cn(nn2)-c2ccc(NC(=O)Nc3ccccc3C)cc2)CC1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552029
(CHEMBL4758562)Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-n1cc(CCCN2CCOCC2)nn1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.38E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
ATP-dependent RNA helicase DDX3X
(Homo sapiens (Human)) | BDBM50552030
(CHEMBL4743223)Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-n1cc(CCN2CCOCC2)nn1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human DDX3X using dsRNA as substrate measured every 30 sec for 40 mins by FRET assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112319 BindingDB Entry DOI: 10.7270/Q23J3HMG |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368038
(CHEMBL1203655)Show SMILES CCOC(=O)C1=C(COCCc2ccncc2)N=C(C)C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC |c:5,t:18| Show InChI InChI=1S/C25H27N3O7/c1-4-35-25(30)23-20(15-34-13-10-17-8-11-26-12-9-17)27-16(2)21(24(29)33-3)22(23)18-6-5-7-19(14-18)28(31)32/h5-9,11-12,14,21-22H,4,10,13,15H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 7.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50368035
(CHEMBL1203656)Show SMILES CCOC(=O)C1=C(COCCn2ccnc2)N=C(C)C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC |c:5,t:17| Show InChI InChI=1S/C23H26N4O7/c1-4-34-23(29)21-18(13-33-11-10-26-9-8-24-14-26)25-15(2)19(22(28)32-3)20(21)16-6-5-7-17(12-16)27(30)31/h5-9,12,14,19-20H,4,10-11,13H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.15E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthetase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50014915
(4-(2-Chloro-3-trifluoromethyl-phenyl)-2-imidazol-1...)Show SMILES CCOC(=O)C1C(C(C(=O)OC)=C(Cn2ccnc2)N=C1C)c1cccc(c1Cl)C(F)(F)F |c:20,t:11| Show InChI InChI=1S/C22H21ClF3N3O4/c1-4-33-21(31)16-12(2)28-15(10-29-9-8-27-11-29)18(20(30)32-3)17(16)13-6-5-7-14(19(13)23)22(24,25)26/h5-9,11,16-17H,4,10H2,1-3H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.25E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50318494
(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)Show SMILES CCOC(=O)C1=C(C)N=C(C)C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC |c:5,t:8| Show InChI InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,14,16H,5H2,1-4H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK
Curated by ChEMBL
| Assay Description Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg |
J Med Chem 33: 646-52 (1990)
BindingDB Entry DOI: 10.7270/Q25X29HP |
More data for this Ligand-Target Pair | |