| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenosine receptor A2a/A2b |
|---|
| Ligand | BDBM50015829 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_30535 (CHEMBL643182) |
|---|
| IC50 | 33±n/a nM |
|---|
| Citation |  Sarges, R; Howard, HR; Browne, RG; Lebel, LA; Seymour, PA; Koe, BK 4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants. J Med Chem33:2240-54 (1990) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenosine receptor A2a/A2b |
|---|
| Name: | Adenosine receptor A2a/A2b |
|---|
| Synonyms: | Adenosine A2 receptor |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 30560 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Adenosine receptor A2b |
|---|
| Synonyms: | AA2BR_RAT | Adenosine receptor | Adora2b |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 36378.84 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_32934 |
|---|
| Residue: | 332 |
|---|
| Sequence: | MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFA
IPFAITISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGT
RARGIIAVLWVLAFGIGLTPFLGWNSKDRATSNCTEPGDGITNKSCCPVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMMVIYIKIFMVACKQLQHMELMEHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAINCITLFHPALAKDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYS
FHRIISRYVLCQTDTKGGSGQAGGQSTFSLSL
|
|
|
|---|
| Component 2 |
| Name: | Adenosine receptor A2a |
|---|
| Synonyms: | AA2AR_RAT | ADENOSINE A2a | Adenosine A2 receptor | Adenosine A2a receptor (A2a) | Adenosine Receptors A2a (A2a) | Adenosine receptor A2a and A3 | Adenosine receptors A2a | Adora2a | Rat striatal adenosine A2a receptor |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 45015.65 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Rat A2A receptors expressed in CHO cells. |
|---|
| Residue: | 410 |
|---|
| Sequence: | MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFA
ITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKG
IIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAF
VLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALC
WLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRT
HVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGL
GGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
|
|
|
|---|
| BDBM50015829 |
|---|
| n/a |
|---|
| Name | BDBM50015829 |
|---|
| Synonyms: | 8-Chloro-1-(4-chloro-phenyl)-[1,2,4]triazolo[4,3-a]quinoxalin-4-ylamine | CHEMBL73095 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H9Cl2N5 |
|---|
| Mol. Mass. | 330.171 |
|---|
| SMILES | Nc1nc2ccc(Cl)cc2n2c(nnc12)-c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
