| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50367055 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54214 |
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| IC50 | 25±n/a nM |
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| Citation |  Rosowsky, A; Forsch, RA; Moran, RG; Freisheim, JH Synthesis and biological activity of the 2-desamino and 2-desamino-2-methyl analogues of aminopterin and methotrexate. J Med Chem34:227-34 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50367055 |
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| n/a |
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| Name | BDBM50367055 |
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| Synonyms: | 4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTERIN | Aminopteroylglutamic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N8O5 |
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| Mol. Mass. | 440.4127 |
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| SMILES | Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1 |r| |
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| Structure | 
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