| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
|---|
| Ligand | BDBM50007341 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_145801 |
|---|
| IC50 | 17±n/a nM |
|---|
| Citation |  Barlow, JJ; Blackburn, TP; Costello, GF; James, R; Le Count, DJ; Main, BG; Pearce, RJ; Russell, K; Shaw, JS Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]acetamides: a novel series of potent and selective kappa-opioid agonists. J Med Chem34:3149-58 (1991) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kappa-type opioid receptor |
|---|
| Name: | Kappa-type opioid receptor |
|---|
| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 42744.99 |
|---|
| Organism: | Cavia porcellus (domestic guinea pig) |
|---|
| Description: | P41144 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
|
|
|
|---|
| BDBM50007341 |
|---|
| n/a |
|---|
| Name | BDBM50007341 |
|---|
| Synonyms: | 2-(3,4-Dichloro-phenyl)-N-[1-(2-methoxy-phenyl)-2-pyrrolidin-1-yl-ethyl]-N-methyl-acetamide | CHEMBL106211 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H26Cl2N2O2 |
|---|
| Mol. Mass. | 421.36 |
|---|
| SMILES | COc1ccccc1C(CN1CCCC1)N(C)C(=O)Cc1ccc(Cl)c(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
