| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-dependent protein kinase catalytic subunit alpha |
|---|
| Ligand | BDBM83205 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_161880 |
|---|
| IC50 | 98±n/a nM |
|---|
| Citation |  Shearer, BG; Sullivan, JP; Carter, JP; Mathew, RM; Waid, P; Connor, JR; Patch, RJ; Burch, RM Substituted 2-(aminomethyl)piperidines: a novel class of selective protein kinase C inhibitors. J Med Chem34:2928-31 (1991) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-dependent protein kinase catalytic subunit alpha |
|---|
| Name: | cAMP-dependent protein kinase catalytic subunit alpha |
|---|
| Synonyms: | KAPCA_RAT | PKA, catalytic subunit | Prkaca | cAMP-Dependent Protein Kinase (PKA) | cAMP-dependent protein kinase alpha-catalytic subunit |
|---|
| Type: | Enzyme catalytic subunit |
|---|
| Mol. Mass.: | 40627.70 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | The catalytic subunit of cAMP-dependent protein kinase (PKA) was used in the assay. It did not require cAMP for activity. |
|---|
| Residue: | 351 |
|---|
| Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWEDPSQNTAQLDHFDRIKTLGTGSFGRVML
VKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF
|
|
|
|---|
| BDBM83205 |
|---|
| n/a |
|---|
| Name | BDBM83205 |
|---|
| Synonyms: | (E,2S,3R)-2-amino-4-octadecene-1,3-diol | (E,2S,3R)-2-aminooctadec-4-ene-1,3-diol | (E,2S,3R)-2-azanyloctadec-4-ene-1,3-diol | MLS-0412588.0001 | cid_5280335 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H37NO2 |
|---|
| Mol. Mass. | 299.4919 |
|---|
| SMILES | CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO |
|---|
| Structure | 
|
|---|
Search and Browse
