| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50002098 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_83429 |
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| Ki | 6.3±n/a nM |
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| Citation |  Ohshima, E; Otaki, S; Sato, H; Kumazawa, T; Obase, H; Ishii, A; Ishii, H; Ohmori, K; Hirayama, N Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivatives. J Med Chem35:2074-84 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55641.53 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | Guinea pig cerebellum was used in binding assay. |
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| Residue: | 488 |
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| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
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| BDBM50002098 |
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| n/a |
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| Name | BDBM50002098 |
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| Synonyms: | 11-(4-Dimethylamino-butylidene)-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid | CHEMBL304042 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23NO3 |
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| Mol. Mass. | 337.4122 |
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| SMILES | CN(C)CCC\C=C1/c2ccccc2COc2ccc(cc12)C(O)=O |
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| Structure | 
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