| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin D |
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| Ligand | BDBM50006864 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_44968 |
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| IC50 | 763±n/a nM |
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| Citation |  Patt, WC; Hamilton, HW; Taylor, MD; Ryan, MJ; Taylor, DG; Connolly, CJ; Doherty, AM; Klutchko, SR; Sircar, I; Steinbaugh, BA Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors. J Med Chem35:2562-72 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin D |
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| Name: | Cathepsin D |
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| Synonyms: | CATD_BOVIN | CTSD |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42158.92 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_1458606 |
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| Residue: | 387 |
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| Sequence: | VIRIPLHKFTSIRRTMSEAAGVLIAKGPISKYATGEPAVRQGPIPELLKNYMDAQYYGEI
GIGTPPQCFTVVFDTGSANLWVPSIHCKLLDIACWTHRKYNSDKSSTYVKNGTTFDIHYG
SGSLSGYLSQDTVSVPCNPSSSSPGGVTVQRQTFGEAIKQPGVVFIAAKFDGILGMAYPR
ISVNNVLPVFDNLMQQKLVDKNVFSFFLNRDPKAQPGGELMLGGTDSKYYRGSLMFHNVT
RQAYWQIHMDQLDVGSSLTVCKGGCEAIVDTGTSLIVGPVEEVRELQKAIGAVPLIQGEY
MIPCEKVSSLPEVTVKLGGKDYALSPEDYALKVSQAETTVCLSGFMGMDIPPPGGPLWIL
GDVFIGRYYTVFDRDQNRVGLAEAARL
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| BDBM50006864 |
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| n/a |
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| Name | BDBM50006864 |
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| Synonyms: | CHEMBL420417 | {1-[2-(2-Amino-thiazol-4-yl)-1-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C34H53N5O6S |
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| Mol. Mass. | 659.88 |
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| SMILES | CC(C)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1csc(N)n1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C |
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| Structure | 
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