| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
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| Ligand | BDBM50003811 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_28352 |
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| IC50 | 47±n/a nM |
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| Citation |  Harris, NV; Smith, C; Ashton, MJ; Bridge, AW; Bush, RC; Coffee, EC; Dron, DI; Harper, MF; Lythgoe, DJ; Newton, CG Acyl-CoA:cholesterol O-acyl transferase (ACAT) inhibitors. 1. 2-(Alkylthio)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem35:4384-92 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 1 |
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| Name: | Sterol O-acyltransferase 1 |
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| Synonyms: | ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64165.56 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_28796 |
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| Residue: | 545 |
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| Sequence: | MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
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|
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| BDBM50003811 |
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| n/a |
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| Name | BDBM50003811 |
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| Synonyms: | 2-(3-[1,3]Dioxan-2-yl-propylsulfanyl)-4,5-diphenyl-1H-imidazole | CHEMBL136063 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N2O2S |
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| Mol. Mass. | 380.503 |
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| SMILES | C(CSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)CC1OCCCO1 |
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| Structure | 
|
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