Reaction Details |
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Target | Sterol O-acyltransferase 1 |
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Ligand | BDBM50003822 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_28352 |
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IC50 | 580±n/a nM |
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Citation | Harris, NV; Smith, C; Ashton, MJ; Bridge, AW; Bush, RC; Coffee, EC; Dron, DI; Harper, MF; Lythgoe, DJ; Newton, CG Acyl-CoA:cholesterol O-acyl transferase (ACAT) inhibitors. 1. 2-(Alkylthio)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem35:4384-92 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sterol O-acyltransferase 1 |
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Name: | Sterol O-acyltransferase 1 |
Synonyms: | ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat |
Type: | PROTEIN |
Mol. Mass.: | 64165.56 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_28796 |
Residue: | 545 |
Sequence: | MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
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BDBM50003822 |
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n/a |
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Name | BDBM50003822 |
Synonyms: | 2-(2,2-Dimethoxy-ethylsulfanyl)-4,5-diphenyl-1H-imidazole | CHEMBL337308 |
Type | Small organic molecule |
Emp. Form. | C19H20N2O2S |
Mol. Mass. | 340.439 |
SMILES | COC(CSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)OC |
Structure |
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