| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA topoisomerase 1 |
|---|
| Ligand | BDBM50045379 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_208261 |
|---|
| IC50 | 220±n/a nM |
|---|
| Citation |  Wall, ME; Wani, MC; Nicholas, AW; Manikumar, G; Tele, C; Moore, L; Truesdale, A; Leitner, P; Besterman, JM Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs. J Med Chem36:2689-700 (1993) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA topoisomerase 1 |
|---|
| Name: | DNA topoisomerase 1 |
|---|
| Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 90771.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11387 |
|---|
| Residue: | 765 |
|---|
| Sequence: | MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
|
|
|
|---|
| BDBM50045379 |
|---|
| n/a |
|---|
| Name | BDBM50045379 |
|---|
| Synonyms: | (20RS)-7-ethyl-7-hydroxy-15-nitro-7,8,11,13-tetrahydro-10H-[1,3]dioxolo[5,4-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11-dione | (20S)-7-ethyl-7-hydroxy-15-nitro-7,8,11,13-tetrahydro-10H-[1,3]dioxolo[5,4-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11-dione | CHEMBL329664 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H15N3O8 |
|---|
| Mol. Mass. | 437.3591 |
|---|
| SMILES | CCC1(O)C(=O)OCc2c1cc1-c3nc4cc5OCOc5c([N+]([O-])=O)c4cc3Cn1c2=O |
|---|
| Structure | 
|
|---|
Search and Browse
