| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50042807 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_162036 |
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| IC50 | 25±n/a nM |
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| Citation |  Erion, MD; Niwas, S; Rose, JD; Ananthan, S; Allen, M; Secrist, JA; Babu, YS; Bugg, CE; Guida, WC; Ealick, SE Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group. J Med Chem36:3771-83 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50042807 |
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| n/a |
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| Name | BDBM50042807 |
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| Synonyms: | 2-Amino-7-[1-(3-chloro-phenyl)-3-hydroxy-propyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL331949 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15ClN4O2 |
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| Mol. Mass. | 318.758 |
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| SMILES | Nc1nc2c(c[nH]c2c(=O)[nH]1)C(CCO)c1cccc(Cl)c1 |
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| Structure | 
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