| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM50043303 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_62177 (CHEMBL672116) |
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| IC50 | 0.300000±n/a nM |
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| Citation |  He, X; Raymon, LP; Mattson, MV; Eldefrawi, ME; de Costa, BR Further studies of the structure-activity relationships of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine. Synthesis and evaluation of 1-(2-benzo[b]thienyl)-N,N-dialkylcyclohexylamines at dopamine uptake and phencyclidine binding sites. J Med Chem36:4075-81 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 68749.45 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P23977 |
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| Residue: | 619 |
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| Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
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| BDBM50043303 |
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| n/a |
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| Name | BDBM50043303 |
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| Synonyms: | (1-Benzo[b]thiophen-2-yl-cyclohexyl)-butyl-amine | CHEMBL335006 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H25NS |
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| Mol. Mass. | 287.463 |
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| SMILES | CCCCNC1(CCCCC1)c1cc2ccccc2s1 |
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| Structure | 
|
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