| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
|---|
| Ligand | BDBM50046869 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_153326 (CHEMBL760478) |
|---|
| Ki | 12400±n/a nM |
|---|
| Citation |  Chern, JW; Lee, HY; Chen, CS; Shewach, DS; Daddona, PE; Townsend, LB Nucleosides. 5. Synthesis of guanine and formycin B derivatives as potential inhibitors of purine nucleoside phosphorylase. J Med Chem36:1024-31 (1993) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Purine nucleoside phosphorylase |
|---|
| Name: | Purine nucleoside phosphorylase |
|---|
| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 32119.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 289 |
|---|
| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
|
|
|
|---|
| BDBM50046869 |
|---|
| n/a |
|---|
| Name | BDBM50046869 |
|---|
| Synonyms: | 2,8-Diamino-9-hexyl-1,9-dihydro-purin-6-one | CHEMBL8587 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H18N6O |
|---|
| Mol. Mass. | 250.3002 |
|---|
| SMILES | CCCCCCn1c(N)nc2c1nc(N)[nH]c2=O |
|---|
| Structure | 
|
|---|
Search and Browse
