Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50041671 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54442 (CHEMBL669645) |
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IC50 | 60±n/a nM |
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Citation | Kotake, Y; Iijima, A; Yoshimatsu, K; Tamai, N; Ozawa, Y; Koyanagi, N; Kitoh, K; Nomura, H Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids. J Med Chem37:1616-24 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_MOUSE | Dhfr |
Type: | Enzyme |
Mol. Mass.: | 21608.82 |
Organism: | Mus musculus (Mouse) |
Description: | n/a |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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BDBM50041671 |
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n/a |
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Name | BDBM50041671 |
Synonyms: | 2-{4-[3-(2-Amino-4-hydroxy-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-propyl]-benzoylamino}-pentanedioic acid | CHEMBL42301 |
Type | Small organic molecule |
Emp. Form. | C22H26N4O6 |
Mol. Mass. | 442.465 |
SMILES | Nc1nc2CCC(CCCc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)c2c(=O)[nH]1 |
Structure |
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