| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neutrophil elastase |
|---|
| Ligand | BDBM50039637 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_63980 (CHEMBL677606) |
|---|
| Ki | 0.01±n/a nM |
|---|
| Citation |  Subramanyam, C; Bell, MR; Carabateas, P; Court, JJ; Dority, JA; Ferguson, E; Gordon, R; Hlasta, DJ; Kumar, V; Saindane, M 2,6-Disubstituted aryl carboxylic acids, leaving groups"par excellence" for benzisothiazolone inhibitors of human leukocyte elastase. J Med Chem37:2623-6 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neutrophil elastase |
|---|
| Name: | Neutrophil elastase |
|---|
| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28532.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08246 |
|---|
| Residue: | 267 |
|---|
| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
|
|
|
|---|
| BDBM50039637 |
|---|
| n/a |
|---|
| Name | BDBM50039637 |
|---|
| Synonyms: | 2,6-Dichloro-3-[(2-dimethylamino-ethyl)-methyl-sulfamoyl]-benzoic acid 4-isopropyl-1,1,3-trioxo-2,3-dihydro-1H-1lambda*6*-benzo[b]thiophen-2-ylmethyl ester; hydrochloride | CHEMBL538776 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H28Cl2N2O7S2 |
|---|
| Mol. Mass. | 591.524 |
|---|
| SMILES | CC(C)c1cccc2c1C(=O)C(COC(=O)c1c(Cl)ccc(c1Cl)S(=O)(=O)N(C)CCN(C)C)S2(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
