| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM50039845 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_138335 (CHEMBL747765) |
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| IC50 | 320000±n/a nM |
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| Citation |  Dunbar, PG; Durant, GJ; Rho, T; Ojo, B; Huzl, JJ; Smith, DA; el-Assadi, AA; Sbeih, S; Ngur, DO; Periyasamy, S Design, synthesis, and neurochemical evaluation of 2-amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines and 2-amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem37:2774-82 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51390.46 |
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| Organism: | RAT |
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| Description: | P08482 |
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| Residue: | 460 |
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| Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM50039845 |
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| n/a |
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| Name | BDBM50039845 |
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| Synonyms: | 2-Amino-3,4,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester; hydrochloride | CHEMBL552914 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H12N2O2 |
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| Mol. Mass. | 156.1824 |
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| SMILES | COC(=O)C1CCCN=C1N |c:8| |
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| Structure | 
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