| Reaction Details |
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 | Report a problem with these data |
| Target | Translocator protein |
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| Ligand | BDBM50041490 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_37642 (CHEMBL650286) |
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| IC50 | 646±n/a nM |
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| Citation |  Greco, G; Novellino, E; Fiorini, I; Nacci, V; Campiani, G; Ciani, SM; Garofalo, A; Bernasconi, P; Mennini, T A comparative molecular field analysis model for 6-arylpyrrolo[2,1-d] [1,5]benzothiazepines binding selectively to the mitochondrial benzodiazepine receptor. J Med Chem37:4100-8 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Translocator protein |
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| Name: | Translocator protein |
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| Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
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| Type: | Mitochondrion membrane protein |
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| Mol. Mass.: | 18945.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
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| Residue: | 169 |
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| Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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| BDBM50041490 |
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| n/a |
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| Name | BDBM50041490 |
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| Synonyms: | Acetic acid 9-chloro-5-(4-methoxy-phenyl)-6-thia-10b-aza-benzo[e]azulen-4-yl ester | CHEMBL32657 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16ClNO3S |
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| Mol. Mass. | 397.875 |
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| SMILES | COc1ccc(cc1)C1=C(OC(C)=O)c2cccn2-c2cc(Cl)ccc2S1 |c:9| |
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| Structure | 
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