| Reaction Details |
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 | Report a problem with these data |
| Target | Neprilysin |
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| Ligand | BDBM50048310 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_144596 (CHEMBL747371) |
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| IC50 | 3±n/a nM |
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| Citation |  Fink, CA; Qiao, Y; Berry, CJ; Sakane, Y; Ghai, RD; Trapani, AJ New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11. J Med Chem38:5023-30 (1996) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neprilysin |
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| Name: | Neprilysin |
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| Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 |
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| Type: | Protein |
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| Mol. Mass.: | 85789.59 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P07861 |
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| Residue: | 750 |
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| Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
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| BDBM50048310 |
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| n/a |
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| Name | BDBM50048310 |
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| Synonyms: | (S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-cyclopentanecarbonyl]-amino}-3-pyridin-2-yl-propionic acid | CHEMBL356343 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H27N3O4S |
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| Mol. Mass. | 393.5 |
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| SMILES | CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1ccccn1)C(O)=O |
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| Structure | 
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