Reaction Details |
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Target | Neprilysin |
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Ligand | BDBM50048319 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_144596 (CHEMBL747371) |
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IC50 | 16±n/a nM |
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Citation | Fink, CA; Qiao, Y; Berry, CJ; Sakane, Y; Ghai, RD; Trapani, AJ New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11. J Med Chem38:5023-30 (1996) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neprilysin |
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Name: | Neprilysin |
Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 |
Type: | Protein |
Mol. Mass.: | 85789.59 |
Organism: | Rattus norvegicus (Rat) |
Description: | P07861 |
Residue: | 750 |
Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
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BDBM50048319 |
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n/a |
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Name | BDBM50048319 |
Synonyms: | (S)-3-Biphenyl-4-yl-2-{[1-((S)-2-mercapto-3-methyl-1-oxo-butylamino)-cyclopentanecarbonyl]-amino}-propionic acid | (S)-3-Biphenyl-4-yl-2-{[1-((S)-2-mercapto-3-methyl-butyrylamino)-cyclopentanecarbonyl]-amino}-propionic acid | 3-Biphenyl-4-yl-2-{[1-(2-mercapto-3-methyl-butyrylamino)-cyclopentanecarbonyl]-amino}-propionic acid | CGS-30084 | CHEMBL64081 |
Type | Small organic molecule |
Emp. Form. | C26H32N2O4S |
Mol. Mass. | 468.608 |
SMILES | CC(C)[C@H](S)C(=O)NC1(CCCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O |
Structure |
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