Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50034601 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_148687 (CHEMBL751061) |
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IC50 | 180±n/a nM |
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Citation | Bertha, CM; Flippen-Anderson, JL; Rothman, RB; Porreca, F; Davis, P; Xu, H; Becketts, K; Cha, XY; Rice, KC Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands. J Med Chem38:1523-37 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50034601 |
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n/a |
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Name | BDBM50034601 |
Synonyms: | 3-[13-cyclopropylmethyl-9,13-diazatetracyclo[10.3.1.02,10.03,8]hexadeca-2(10),3(8),4,6-tetraen-1-yl]phenol | CHEMBL38086 |
Type | Small organic molecule |
Emp. Form. | C24H26N2O |
Mol. Mass. | 358.476 |
SMILES | Oc1cccc(c1)C12CCN(CC3CC3)C(Cc3[nH]c4ccccc4c13)C2 |
Structure |
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