Reaction Details |
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Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
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Ligand | BDBM50049055 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_155188 (CHEMBL761835) |
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IC50 | 10±n/a nM |
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Citation | Nomoto, Y; Takai, H; Ohno, T; Nagashima, K; Yao, K; Yamada, K; Kubo, K; Ichimura, M; Mihara, A; Kase, H Studies of cardiotonic agents. 8. Synthesis and biological activities of optically active 6-(4-(benzylamino)-7-quinazolinyl)-4,5-dihydro-5-methyl-3(2H)- pyridazinone (KF15232). J Med Chem39:297-303 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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cGMP-specific 3',5'-cyclic phosphodiesterase |
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Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
Synonyms: | PDE5 | PDE5A | PDE5A_BOVIN | Phosphodiesterase 5A |
Type: | PROTEIN |
Mol. Mass.: | 98615.45 |
Organism: | Bos taurus |
Description: | ChEMBL_155186 |
Residue: | 865 |
Sequence: | MERAGPGSARPQQQWDQDSVEAWLDDHWDFTFSYFVRKGTREMVNAWFAERVHTIPVCKE
GIKGHTESCSCPLQPSPRAESSVPGTPTRKISASEFDRPLRPIVIKDSEGTVSFLSDSDK
KEQMPLTSPRFDNDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLV
CEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPR
FNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFC
GIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIF
IVDEDCSDSFSSVFHMECEELEKSSDTLTRERDANRINYMYAQYVKNTMEPLNIPDVSKD
KRFPWTNENMGNINQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEETTGKVKAFNRNDEQ
FLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPS
AQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCKWILSVKKNYRKNV
AYHNWRHAFNTAQCMFAALKAGKIQKRLTDLEILALLIAALSHDLDHRGVNNSYIQRSEH
PLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIK
RRGEFFELIMKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQG
DRERKELNIEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNR
QKWQALAEQQEKTLINGESSQTKRN
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BDBM50049055 |
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n/a |
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Name | BDBM50049055 |
Synonyms: | (R)-6-(4-Benzylamino-quinazolin-7-yl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one | CHEMBL103976 |
Type | Small organic molecule |
Emp. Form. | C20H19N5O |
Mol. Mass. | 345.3978 |
SMILES | C[C@@H]1CC(=O)NN=C1c1ccc2c(NCc3ccccc3)ncnc2c1 |c:6| |
Structure |
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