Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Ligand | BDBM50054585 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_52873 (CHEMBL666232) |
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IC50 | 89±n/a nM |
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Citation | Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds. J Med Chem39:4608-21 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | Dhodh | Dihydroorotate dehydrogenase | PYRD_MOUSE |
Type: | PROTEIN |
Mol. Mass.: | 42711.08 |
Organism: | Mus musculus |
Description: | ChEMBL_1366444 |
Residue: | 395 |
Sequence: | MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVR
VISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSV
TPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGIN
LGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQER
DALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTF
LGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR
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BDBM50054585 |
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n/a |
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Name | BDBM50054585 |
Synonyms: | (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoromethanesulfonyl-phenyl)-acrylamide | CHEMBL356115 |
Type | Small organic molecule |
Emp. Form. | C14H11F3N2O4S |
Mol. Mass. | 360.308 |
SMILES | FC(F)(F)S(=O)(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 |
Structure |
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