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TargetKappa-type opioid receptor
LigandBDBM50049560
Substrate/Competitorn/a
Meas. Tech.ChEMBL_146390
Ki 5.8±n/a nM
Citation Bolognesi MLOjala WHGleason WBGriffin JFFarouz-Grant FLarson DLTakemori AEPortoghese PS Opioid antagonist activity of naltrexone-derived bivalent ligands: importance of a properly oriented molecular scaffold to guide"address" recognition at kappa opioid receptors. J Med Chem 39:1816-22 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kappa-type opioid receptor
Name:Kappa-type opioid receptor
Synonyms:Kappa Opioid Receptor | OPIATE Kappa | Opiate Kappa 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42744.99
Organism:Cavia porcellus (domestic guinea pig)
Description:P41144
Residue:380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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  Blast E-value cutoff:
BDBM50049560
n/a
NameBDBM50049560
Synonyms:(4S,5'R,13'R,17'S)-2-[(5R,13R,14R,17S)-14-amino-4- (cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4- azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca- 7(18),8,10-trien-14-yl]-4'-(cyclopropylmethyl)- 10',17'-dihydroxy-3,5-dihydro-12'-oxa-4'- azaspiro[imidazole-4,14'- pentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadecane]- 7',9',11'(18')-trien-5-one | CHEMBL298574
TypeSmall organic molecule
Emp. Form.C42H49N5O7
Mol. Mass.735.8678
SMILESN[C@]1(CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1C2(CCN3CC1CC1)c45)C1=N[C@]2(CC[C@@]3(O)[C@H]4Cc5ccc(O)c6O[C@@H]2C3(CCN4CC2CC2)c56)C(=O)N1 |t:31,TLB:46:45:30:50.34.33,20:19:4:24.8.7|
Structure
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