| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50049560 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_146390 (CHEMBL753186) |
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| Ki | 5.8±n/a nM |
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| Citation |  Bolognesi, ML; Ojala, WH; Gleason, WB; Griffin, JF; Farouz-Grant, F; Larson, DL; Takemori, AE; Portoghese, PS Opioid antagonist activity of naltrexone-derived bivalent ligands: importance of a properly oriented molecular scaffold to guide"address" recognition at kappa opioid receptors. J Med Chem39:1816-22 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42744.99 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | P41144 |
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| Residue: | 380 |
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| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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| BDBM50049560 |
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| n/a |
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| Name | BDBM50049560 |
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| Synonyms: | (4S,5'R,13'R,17'S)-2-[(5R,13R,14R,17S)-14-amino-4- (cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4- azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca- 7(18),8,10-trien-14-yl]-4'-(cyclopropylmethyl)- 10',17'-dihydroxy-3,5-dihydro-12'-oxa-4'- azaspiro[imidazole-4,14'- pentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadecane]- 7',9',11'(18')-trien-5-one | CHEMBL298574 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H49N5O7 |
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| Mol. Mass. | 735.8678 |
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| SMILES | N[C@]1(CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1C2(CCN3CC1CC1)c45)C1=N[C@]2(CC[C@@]3(O)[C@H]4Cc5ccc(O)c6O[C@@H]2C3(CCN4CC2CC2)c56)C(=O)N1 |t:31,TLB:46:45:30:50.34.33,20:19:4:24.8.7| |
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| Structure | 
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