| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M3 |
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| Ligand | BDBM50046723 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_138834 (CHEMBL753022) |
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| EC50 | 1100±n/a nM |
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| Citation |  Messer, WS; Abuh, YF; Liu, Y; Periyasamy, S; Ngur, DO; Edgar, MA; El-Assadi, AA; Sbeih, S; Dunbar, PG; Roknich, S; Rho, T; Fang, Z; Ojo, B; Zhang, H; Huzl, JJ; Nagy, PI Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists. J Med Chem40:1230-46 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M3 |
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| Name: | Muscarinic acetylcholine receptor M3 |
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| Synonyms: | ACM3_MOUSE | Chrm-3 | Chrm3 | Mm3 mAChR | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66232.94 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_138834 |
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| Residue: | 589 |
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| Sequence: | MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVSQLDSYNISQTSGNFSSNDTSSDPLG
GHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVIS
MNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRT
TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFY
MPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGTK
RSSRRKYGGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSET
RAIYSIVLKLPGHSTILNSTKLPSSDNLQVPDKDLGTMDVERNAHKLQAQKSMDDRDNCQ
KDFSKLPIQLESAVDTAKTSDTNSSVDKTTAALPLSFKEATLAKRFALKTRSQITKRKRM
SLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNP
VCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
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| BDBM50046723 |
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| n/a |
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| Name | BDBM50046723 |
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| Synonyms: | 5-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1,4,5,6-tetrahydro-pyrimidine; TFA | CHEMBL277014 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H10N4O |
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| Mol. Mass. | 166.1805 |
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| SMILES | Cc1noc(n1)C1CNC=NC1 |c:10| |
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| Structure | 
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