Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50062010

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_48268 (CHEMBL663173)

IC50

268±n/a nM

Citation

Trivedi, BK; Padia, JK; Holmes, A; Rose, S; Wright, DS; Hinton, JP; Pritchard, MC; Eden, JM; Kneen, C; Webdale, L; Suman-Chauhan, N; Boden, P; Singh, L; Field, MJ; Hill, D Second generation"peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile. J Med Chem41:38-45 (1998) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49196.59

Organism:

MOUSE

Description:

Cholecystokinin A CCKBR MOUSE::P56481

Residue:

453

Sequence:

MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWL
LSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGL
ISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCY
VQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANT
WRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPR
ARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50062010

n/a

Name

BDBM50062010

Synonyms:

CHEMBL138190 | [(R)-1-(1-Hydroxymethyl-cyclopentylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester

Type

Small organic molecule

Emp. Form.

C29H39N3O4

Mol. Mass.

493.6377

SMILES

C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCC1 |wU:1.13,wD:1.0,TLB:18:19:16.17.22:23,15:16:23:19.25.20,THB:18:17:23:19.25.20,20:21:16:19.18.25,20:19:16:21.22.23,(1.86,-7.02,;1.88,-8.39,;1.95,-9.93,;3.33,-10.63,;2.08,-11.55,;2.56,-13.02,;4.1,-13.01,;5.13,-14.16,;6.63,-13.84,;7.1,-12.36,;6.07,-11.23,;4.57,-11.55,;.49,-7.87,;-.8,-8.73,;-.77,-10.19,;-2.19,-8.04,;-3.48,-8.89,;-4.87,-8.32,;-6.22,-8.8,;-6.22,-10.28,;-7.41,-11.56,;-5.91,-11.14,;-5.91,-9.55,;-4.51,-11.71,;-3.48,-10.42,;-4.88,-10.77,;3.16,-7.71,;3.14,-6.33,;4.41,-8.43,;5.74,-7.68,;6.14,-9.16,;7.64,-9.56,;5.91,-6.14,;7.42,-5.81,;8.19,-7.15,;7.16,-8.29,)|

Structure