| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin B |
|---|
| Ligand | BDBM50065396 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_47431 (CHEMBL662618) |
|---|
| Ki | 45±n/a nM |
|---|
| Citation |  Chatterjee, S; Gu, ZQ; Dunn, D; Tao, M; Josef, K; Tripathy, R; Bihovsky, R; Senadhi, SE; O'Kane, TM; McKenna, BA; Mallya, S; Ator, MA; Bozyczko-Coyne, D; Siman, R; Mallamo, JP D-amino acid containing, high-affinity inhibitors of recombinant human calpain I. J Med Chem41:2663-6 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin B |
|---|
| Name: | Cathepsin B |
|---|
| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37819.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_63102437 |
|---|
| Residue: | 339 |
|---|
| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
|
|
|
|---|
| BDBM50065396 |
|---|
| n/a |
|---|
| Name | BDBM50065396 |
|---|
| Synonyms: | (R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-ethanesulfonylamino-propionamide | CHEMBL89008 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H26N2O5S |
|---|
| Mol. Mass. | 418.507 |
|---|
| SMILES | CCS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O |
|---|
| Structure | 
|
|---|
Search and Browse
