| Reaction Details |
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 | Report a problem with these data |
| Target | Nitric oxide synthase, brain |
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| Ligand | BDBM50230993 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_143377 (CHEMBL752276) |
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| Ki | 840±n/a nM |
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| Citation |  Collins, JL; Shearer, BG; Oplinger, JA; Lee, S; Garvey, EP; Salter, M; Duffy, C; Burnette, TC; Furfine, ES N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. J Med Chem41:2858-71 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nitric oxide synthase, brain |
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| Name: | Nitric oxide synthase, brain |
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| Synonyms: | Constitutive NOS | N-NOS | NC-NOS | NOS type I | NOS type I nNOS | NOS1 | NOS1_HUMAN | Neuronal NOS | Neuronal nitric oxide synthase | Nitric oxide synthase, brain (nNOS) | Nitric oxide synthase, neuronal (nNOS) | Peptidyl-cysteine S-nitrosylase NOS1 | bNOS | nNOS |
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| Type: | Homodimer |
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| Mol. Mass.: | 160985.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29475 |
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| Residue: | 1434 |
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| Sequence: | MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA
GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI
RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP
RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV
DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS
KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF
PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC
VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW
NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ
IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV
RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT
ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV
WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE
IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ
EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF
GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN
SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV
RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV
ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY
EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV
SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP
FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE
PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE
DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS
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| BDBM50230993 |
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| n/a |
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| Name | BDBM50230993 |
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| Synonyms: | (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid | (2S)-2-ammonio-5-{[iminio(methylamino)methyl]amino}pentanoate | (R)-2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | (S)-2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | (S)-2-amino-5-(2-methylguanidino)pentanoic acid | (S)-2-amino-5-(3-methylguanidino)pentanoic acid | 2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | CHEMBL256147 | L-NMMA | N omega-methyl-L-arginine | N(G)-mono-methyl-L-arginine | N(G)-monomethyl-L-arginine | N-Monomethyl-L-arginine | N-gamma-monomethyl-L-arginine | NG-Monomethyl-L-Arginine | NG-monomethyl-L-arginine acetate | Ngamma-monomethyl-L-arginine | Targinine |
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| Type | Small organic molecule |
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| Emp. Form. | C7H16N4O2 |
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| Mol. Mass. | 188.2275 |
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| SMILES | CNC(N)=NCCC[C@H](N)C(O)=O |r,w:4.4| |
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| Structure | 
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