| Reaction Details |
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 | Report a problem with these data |
| Target | Matrix metalloproteinase-9 |
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| Ligand | BDBM50066661 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_105360 (CHEMBL714518) |
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| IC50 | 16±n/a nM |
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| Citation |  Pikul, S; McDow Dunham, KL; Almstead, NG; De, B; Natchus, MG; Anastasio, MV; McPhail, SJ; Snider, CE; Taiwo, YO; Rydel, T; Dunaway, CM; Gu, F; Mieling, GE Discovery of potent, achiral matrix metalloproteinase inhibitors. J Med Chem41:3568-71 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrix metalloproteinase-9 |
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| Name: | Matrix metalloproteinase-9 |
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| Synonyms: | 67 kDa matrix metalloproteinase-9 | 82 kDa matrix metalloproteinase-9 | 92 kDa gelatinase | 92 kDa type IV collagenase | CLG4B | GELB | Gelatinase B | MMP-9 | MMP9 | MMP9_HUMAN | Matrix metalloproteinase 9 (MMP-9) | Matrix metalloproteinase-9 (MMP-9) | Matrix metalloproteinase-9 (MMP9) |
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| Type: | Enzyme |
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| Mol. Mass.: | 78452.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14780 |
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| Residue: | 707 |
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| Sequence: | MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEM
RGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHN
ITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYP
FDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRS
YSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYS
ACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYST
CTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMY
PMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSER
PTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYW
RFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRR
LDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLD
THDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED
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| BDBM50066661 |
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| n/a |
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| Name | BDBM50066661 |
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| Synonyms: | 8,10-Bis-(4-methoxy-benzenesulfonyl)-1,5-dithia-8,10-diaza-spiro[5.5]undecane-9-carboxylic acid hydroxyamide | CHEMBL118848 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N3O8S4 |
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| Mol. Mass. | 589.725 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)N1CC2(CN(C1C(=O)NO)S(=O)(=O)c1ccc(OC)cc1)SCCCS2 |
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| Structure | 
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