| Reaction Details |
|---|
 | Report a problem with these data |
| Target | B2 bradykinin receptor |
|---|
| Ligand | BDBM50067317 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_40265 (CHEMBL656501) |
|---|
| IC50 | 0.130000±n/a nM |
|---|
| Citation |  Abe, Y; Kayakiri, H; Satoh, S; Inoue, T; Sawada, Y; Inamura, N; Asano, M; Aramori, I; Hatori, C; Sawai, H; Oku, T; Tanaka, H A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 3. Discovering bioisosteres of the imidazo[1,2-a] pyridine moiety. J Med Chem41:4062-79 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| B2 bradykinin receptor |
|---|
| Name: | B2 bradykinin receptor |
|---|
| Synonyms: | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKRB2_CAVPO | Bradykinin B2 receptor |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 42217.03 |
|---|
| Organism: | Cavia porcellus |
|---|
| Description: | n/a |
|---|
| Residue: | 372 |
|---|
| Sequence: | MFNITSQVSALNATLAQGNSCLDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHK
SSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSIC
FLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKDYRDEGH
NVTACLIIYPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNNEMQKFKEIQTER
RATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGFLPGCWEHVIDLITQISSYLAYSNSCL
NPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQSENSMGTLRTSISVDRQIHKLQDWA
RSSSEGTPPGLL
|
|
|
|---|
| BDBM50067317 |
|---|
| n/a |
|---|
| Name | BDBM50067317 |
|---|
| Synonyms: | CHEMBL553614 | N-({[2,4-Dichloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-methyl-carbamoyl}-methyl)-3-[6-(2-oxo-pyrrolidin-1-yl)-pyridin-3-yl]-acrylamide; dihydrochloride |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H29Cl2N5O4 |
|---|
| Mol. Mass. | 618.51 |
|---|
| SMILES | CN(C(=O)CNC(=O)\C=C\c1ccc(nc1)N1CCCC1=O)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
