| Reaction Details |
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 | Report a problem with these data |
| Target | B2 bradykinin receptor |
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| Ligand | BDBM50067930 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_40274 (CHEMBL656509) |
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| IC50 | 0.640±n/a nM |
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| Citation |  Abe, Y; Kayakiri, H; Satoh, S; Inoue, T; Sawada, Y; Inamura, N; Asano, M; Aramori, I; Hatori, C; Sawai, H; Oku, T; Tanaka, H A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 4. Discovery of novel frameworks mimicking the active conformation. J Med Chem41:4587-98 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B2 bradykinin receptor |
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| Name: | B2 bradykinin receptor |
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| Synonyms: | B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44467.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | B2 BRADYKININ BDKRB2 HUMAN::P30411 |
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| Residue: | 391 |
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| Sequence: | MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ
PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN
FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV
IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI
TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI
LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP
IQMENSMGTLRTSISVERQIHKLQDWAGSRQ
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| BDBM50067930 |
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| n/a |
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| Name | BDBM50067930 |
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| Synonyms: | 4-[(E)-2-({1-[2,4-Dichloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-1H-pyrrol-2-ylmethyl}-carbamoyl)-vinyl]-N-methyl-benzamide; hydrochloride | CHEMBL553911 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H28Cl2N4O3 |
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| Mol. Mass. | 599.506 |
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| SMILES | CNC(=O)c1ccc(\C=C\C(=O)NCc2cccn2-c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 |
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| Structure | 
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