Reaction Details |
| Report a problem with these data |
Target | Sodium-dependent dopamine transporter |
---|
Ligand | BDBM50068470 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_62150 (CHEMBL675906) |
---|
IC50 | 1.4±n/a nM |
---|
Citation | Kozikowski, AP; Araldi, GL; Prakash, KR; Zhang, M; Johnson, KM Synthesis and biological properties of new 2beta-alkyl- and 2beta-aryl-3-(substituted phenyl)tropane derivatives: stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters. J Med Chem41:4973-82 (1999) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sodium-dependent dopamine transporter |
---|
Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68749.45 |
Organism: | Rattus norvegicus (rat) |
Description: | P23977 |
Residue: | 619 |
Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
|
|
|
BDBM50068470 |
---|
n/a |
---|
Name | BDBM50068470 |
Synonyms: | (2S,8S)-2-Butyl-8-methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane |
Type | Small organic molecule |
Emp. Form. | C19H29N |
Mol. Mass. | 271.4403 |
SMILES | CCCC[C@@H]1C2CCC(CC1c1ccc(C)cc1)N2C |TLB:19:18:10.4.9:6.7,THB:11:10:18:6.7,3:4:18:6.7| |
Structure |
|