| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50088377 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_146677 (CHEMBL753169) |
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| Ki | 0.42±n/a nM |
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| Citation |  Lavecchia, A; Greco, G; Novellino, E; Vittorio, F; Ronsisvalle, G Modeling of kappa-opioid receptor/agonists interactions using pharmacophore-based and docking simulations. J Med Chem43:2124-34 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42744.99 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | P41144 |
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| Residue: | 380 |
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| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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| BDBM50088377 |
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| n/a |
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| Name | BDBM50088377 |
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| Synonyms: | 1-{2-[3-(3,4-Dichloro-phenyl)-2-oxo-tetrahydro-pyrimidin-1-yl]-2-phenyl-ethyl}-pyrrolidinium |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26Cl2N3O |
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| Mol. Mass. | 419.367 |
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| SMILES | Clc1ccc(cc1Cl)N1CCCN([C@H](C[NH+]2CCCC2)c2ccccc2)C1=O |
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| Structure | 
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