| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
|---|
| Ligand | BDBM50001107 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_146677 (CHEMBL753169) |
|---|
| Ki | 0.09±n/a nM |
|---|
| Citation |  Lavecchia, A; Greco, G; Novellino, E; Vittorio, F; Ronsisvalle, G Modeling of kappa-opioid receptor/agonists interactions using pharmacophore-based and docking simulations. J Med Chem43:2124-34 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kappa-type opioid receptor |
|---|
| Name: | Kappa-type opioid receptor |
|---|
| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 42744.99 |
|---|
| Organism: | Cavia porcellus (domestic guinea pig) |
|---|
| Description: | P41144 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
|
|
|
|---|
| BDBM50001107 |
|---|
| n/a |
|---|
| Name | BDBM50001107 |
|---|
| Synonyms: | 2-(3,4-Dichloro-phenyl)-1-(5-hydroxy-1-pyrrolidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone; hydrochloride | CHEMBL554426 | CHEMBL66018 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H24Cl2N2O2 |
|---|
| Mol. Mass. | 419.344 |
|---|
| SMILES | Oc1cccc2C(CN3CCCC3)N(CCc12)C(=O)Cc1ccc(Cl)c(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
