| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphodiesterase |
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| Ligand | BDBM15296 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_156624 (CHEMBL759869) |
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| IC50 | 843±n/a nM |
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| Citation |  Watanabe, N; Adachi, H; Takase, Y; Ozaki, H; Matsukura, M; Miyazaki, K; Ishibashi, K; Ishihara, H; Kodama, K; Nishino, M; Kakiki, M; Kabasawa, Y 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. J Med Chem43:2523-9 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphodiesterase |
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| Name: | Phosphodiesterase |
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| Synonyms: | Phosphodiesterase 3A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108833.33 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_155977 |
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| Residue: | 985 |
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| Sequence: | MGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAATWLVLRLRLGVLMI
ALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAGAAPREHFGSQL
LAGTKEDIPEFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRG
SQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRV
NPAVSFSENYTCSDSEESAEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEP
SPVRRDRSASIKLHEAPSSSAINPDSWKNPVMMTLTKSRSFTSSYAVSASNHVKAKKQSR
PGSLVKISPLSSPCSSALQGTPASSPVSKISTVQFPEPADATAKQGLSSHKALTYTQSAP
DLSPHILTPPVICSSCGRPYSQGNPADGPLERSGPAIQAQSRTDDTAQVTSDYETNNNSD
SSDIVQNEDETECSREPLRKASACSAYTPDTMMFLDKPILAPEPLVMDNLDSIMEHLNTW
NFPIFDLVEKIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYREIPYH
NRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKMYNVPDD
KYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAA
AWNLFMSRTEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDEVGIDW
TNENDRLLVCQMCIKLADINGPAKCKELHLQWTEGIVNEFYEQGDEEASLGLPISPFMDR
SAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEAPKEEETCE
NNDSPRKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIESQSLDQAPQQHSSEQI
QAIKEEDEDKGKPRGEETPTPKPNQ
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|
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| BDBM15296 |
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| n/a |
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| Name | BDBM15296 |
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| Synonyms: | 6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile | 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile | CHEMBL189 | Milrinone | Primacor | US9242982, Milrinone | US9249139, Milrinone |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9N3O |
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| Mol. Mass. | 211.2194 |
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| SMILES | Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N |
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| Structure | 
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