| Reaction Details |
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 | Report a problem with these data |
| Target | D(2) dopamine receptor |
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| Ligand | BDBM50091591 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_61428 (CHEMBL671402) |
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| IC50 | >10000±n/a nM |
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| Citation |  Annoura, H; Nakanishi, K; Toba, T; Takemoto, N; Imajo, S; Miyajima, A; Tamura-Horikawa, Y; Tamura, S Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity. J Med Chem43:3372-6 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| D(2) dopamine receptor |
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| Name: | D(2) dopamine receptor |
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| Synonyms: | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 50931.60 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P61169 |
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| Residue: | 444 |
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| Sequence: | MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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| BDBM50091591 |
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| n/a |
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| Name | BDBM50091591 |
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| Synonyms: | (2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-flourobenzyl)phenyl]-1-piperazinyl}-2-propanol dimethanesulfonate(SUN N8075) | CHEMBL325689 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H36FN3O2 |
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| Mol. Mass. | 477.6134 |
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| SMILES | Cc1cc(OC[C@@H](O)CN2CCN(CC2)c2ccc(Cc3ccc(F)cc3)cc2)c(C)c(C)c1N |
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| Structure | 
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