| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 5 |
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| Ligand | BDBM7581 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_51306 (CHEMBL884356) |
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| IC50 | 300±n/a nM |
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| Citation |  Ducrot, P; Legraverend, M; Grierson, DS 3D-QSAR CoMFA on cyclin-dependent kinase inhibitors. J Med Chem43:4098-108 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 5 |
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| Name: | Cyclin-dependent kinase 5 |
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| Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33308.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 292 |
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| Sequence: | MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH
KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR
NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS
TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP
MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
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| BDBM7581 |
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| n/a |
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| Name | BDBM7581 |
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| Synonyms: | 1-{6-[(4-methoxyphenyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}-3-methylpent-1-yn-3-ol | 1-{9-isopropyl-6-[(4-methoxyphenyl)amino]-9H-purin-2-yl}-3-methylpent-1-yn-3-ol | C-2 alkynylated purine deriv. 5b | CHEMBL23317 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25N5O2 |
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| Mol. Mass. | 379.4555 |
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| SMILES | CCC(C)(O)C#Cc1nc(Nc2ccc(OC)cc2)c2ncn(C(C)C)c2n1 |
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| Structure | 
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