| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor 4 |
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| Ligand | BDBM50094013 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_220568 (CHEMBL841849) |
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| EC50 | 7200±n/a nM |
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| Citation |  Ornstein, PL; Zimmerman, DM; Arnold, MB; Bleisch, TJ; Cantrell, B; Simon, R; Zarrinmayeh, H; Baker, SR; Gates, M; Tizzano, JP; Bleakman, D; Mandelzys, A; Jarvie, KR; Ho, K; Deverill, M; Kamboj, RK Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic acid (AMPA) receptors. J Med Chem43:4354-8 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor 4 |
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| Name: | Glutamate receptor 4 |
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| Synonyms: | GLUR4 | GRIA4 | GRIA4_HUMAN | Glutamate receptor AMPA 3/4 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 100881.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_468628 |
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| Residue: | 902 |
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| Sequence: | MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEA
PFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITP
SFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWH
VSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIA
NLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSAL
TYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGN
VQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVT
TIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTK
IWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFL
DPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLW
FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED
LAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKG
KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGV
LDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKS
RAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASD
LP
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|
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| BDBM50094013 |
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| n/a |
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| Name | BDBM50094013 |
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| Synonyms: | CHEMBL137359 | Propane-2-sulfonic acid [2-(2'-fluoro-biphenyl-4-yl)-ethyl]-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20FNO2S |
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| Mol. Mass. | 321.41 |
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| SMILES | CC(C)S(=O)(=O)NCCc1ccc(cc1)-c1ccccc1F |
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| Structure | 
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