Ki Summary

Reaction Details

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Target

Glyceraldehyde-3-phosphate dehydrogenase, cytosolic

Ligand

BDBM50100467

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_72768 (CHEMBL680373)

IC50

25000±n/a nM

Citation

Bressi, JC; Verlinde, CL; Aronov, AM; Shaw, ML; Shin, SS; Nguyen, LN; Suresh, S; Buckner, FS; Van Voorhis, WC; Kuntz, ID; Hol, WG; Gelb, MH Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. J Med Chem44:2080-93 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Glyceraldehyde-3-phosphate dehydrogenase, cytosolic

Name:

Glyceraldehyde-3-phosphate dehydrogenase, cytosolic

Synonyms:

G3PC_LEIME | GAPC | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase cytosolic | Glyceraldehyde-3-phosphate dehydrogenase, cytosolic

Type:

PROTEIN

Mol. Mass.:

35645.40

Organism:

Leishmania mexicana

Description:

ChEMBL_72768

Residue:

331

Sequence:

MVKVGINGFGRIGRVVFRAAQMRPDIEIVGINDLLDAEYMAYSLKYDSTHGRFDGTVEVI
KGALVVNGKSIRVTSERDPANLKWDEIGVEVVVESTGLFLTQETAHKHIEAGARRVVMTG
PPKDDTPMFVMGVNHTTYKGQPIISNASCTTNCLAPLAKVVNEKYGIVEGLMTTVHATTA
TQKTVDGPSLKDWRGGRGASQNIIPSSTGAPKAVGKVYPALDGKLTGMAFRVPTPNVSVV
DLTVRLEKPATYKDICAAIKAAAEGEMKGILGYTDDEVVSSDFNGVALTSVFDVKAGISL
NDHFVKLVSWYDNETGYSHKVLDLILHTSAR

BDBM50100467

n/a

Name

BDBM50100467

Synonyms:

3,5-Dichloro-N-(4-hydroxy-5-hydroxymethyl-2-{6-[(3-methoxy-naphthalen-1-ylmethyl)-amino]-9H-purin-3-ylmethyl}-tetrahydro-furan-3-yl)-benzamide | CHEMBL64311

Type

Small organic molecule

Emp. Form.

C29H26Cl2N6O5

Mol. Mass.

609.46

SMILES

COc1cc(CNc2ncnc3n(cnc23)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2NC(=O)c2cc(Cl)cc(Cl)c2)c2ccccc2c1

Structure